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. 2020 Sep 3;18:340. doi: 10.1186/s12967-020-02508-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Immunohistochemical evaluation of immune cells in human duodenal cancer. a Representative picture of a human duodenal adenocarcinoma specimen; the invasive front (orange arrow) and tumor core regions (black arrow) are indicated. b–h Representative pictures of CD45RO-TILs (b), CD8-TILs (c), IL17+ cells (d), PD1-TILs (e), CD20-TILs (f), CD68-TAM (h) at the invasive margin and CD20-TLT (g) in the tumor stroma. Scale bars = 500 μm (a), 200 μm (b–h). TILs: tumor-infiltrating lymphocytes; TLT: tertiary lymphoid tissue; TAM: tumor-associated macrophages