Table 11.
CSF findings during acute attacks (first LP/event) and during remission (last LP/event)
| Units | Attack, all, first LP/event | Remission, all, last LP/event | p values | |
|---|---|---|---|---|
| Pleocytosis | Samples | 54/102 (52.9%) | 2/20 (10%) | p = 0.0004 |
| WCC | Cells/μl | 6.5 (0-463; 100) | 2 (0-16; 19) | p < 0.0002 |
| WCC > 100/μl | Samples | 13/101 (12.9%) | 0/20 (0%) | p = n.s. |
| OCB | Samples | 9/96 (9.4%) | 2/20 (10%) | p = n.s. |
| QIgG > Qlim(IgG) | Samples | 6/85 (7.1%) | 1/18 (5.6%) | p = n.s. |
| QIgG | Ratio | 3.47 (0.9-23.61; 84) | 2.66 (1.47-6.7; 18) | p = n.s. |
| IgG-IF > 10% | Samples | 4/84 (4.8%) | 0/18 (0%) | p = n.s. |
| QIgM > Qlim(IgM) | Samples | 11/73 (15.1%) | 0/15 (0%) | p = n.s. |
| QIgM | Ratio | 0.59 (0-13.81; 72) | 0.3 (0-1.36; 15) | p < 0.03 |
| QIgA > Qlim(IgA) | Samples | 3/72 (4.2%) | 1/15 (6.7%) | p = n.s. |
| QIgA | Ratio | 1.76 (0-17.27; 71) | 1.94 (0-4.83; 15) | p = n.s. |
| QAlb > Qlim(Alb) | Samples | 42/88 (47.7%) | 5/18 (27.8%) | p = n.s. |
| QAlb | Ratio | 6.46 (2.98-32.67; 88) | 5.55 (3.13-15.33; 18) | p = n.s. |
| CSF TP elevated | Samples | 42/93 (45.2%) | 5/20 (25%) | p = n.s. |
| CSF TP concentration | mg/dl | 44.5 (20.5-176; 85) | 36.65 (5.11-101; 18) | p = n.s. |
| CSF TP > 100 mg/dl | Samples | 7/93 (7.5%) | 1/20 (5%) | p = n.s. |
| CSF l-lactate elevated | Samples | 16/65 (24.6%) | 0/15 (0%) | p = 0.033 |
| CSF l-lactate concentration | mg/dl | 1.82 (1.05-4.43; 62) | 1.7 (1.33-2.1; 14) | p = n.s. |
| CSF l-lactate > 3 mmol/l | Samples | 4/65 (6.2%) | 0/15 (0%) | p = n.s. |
| Time since attack onset | Days | 8 (0-34; 104) | 191 (117-2624; 20) |
Ratios and concentrations are given as median (with ranges and sample numbers in brackets)
IgG-IF intrathecal IgG fraction; OCB oligoclonal bands; QAlb CSF/serum albumin quotient; TP total protein