Table 2.
Frequency of intrathecal IgG synthesis, oligoclonal IgG pattern, IgG CSF/serum ratios, intrathecal IgG fractions, absolute amount of locally produced IgG, and absolute IgG concentrations in the CSF and serum
| Units | Total | Attack | Remission | Acute MY subgroup | Acute ON subgroup | Acute BRAIN subgroup | |
|---|---|---|---|---|---|---|---|
| Intrathecal IgG synthesis | |||||||
| OCB positive or IgG-IF ≥ 10% | Samples | 20/151 (13.2%) | 13/112 (11.6%) | 2/24 (8.3%) | 7/50 (14%) | 3/51 (5.9%) | 2/10 (20%) |
| OCB positive | Samples | 20/151 (13.2%) | 13/112 (11.6%) | 2/24 (8.3%) | 7/50 (14%) | 3/50 (6%) | 2/10 (20%) |
| OCB pattern 1 | Samples | 101/150 (67.3%) | 77/112 (68.8%) | 18/24 (75%) | 30/50 (60%) | 41/50 (82%) | 5/10 (50%) |
| OCB pattern 2 | Samples | 14/150 (9.3%) | 9/112 (8%) | 2/24 (8.3%) | 3/50 (6%) | 3/50 (6%) | 2/10 (20%) |
| OCB pattern 3 | Samples | 5/150 (3.3%) | 4/112 (3.6%) | 0/24 (0%) | 4/50 (8%) | 0/50 (0%) | 0/10 (0%) |
| OCB pattern 4 | Samples | 28/150 (18.7%) | 20/112 (17.9%) | 4/24 (16.7%) | 11/50 (22%) | 6/50 (12%) | 3/10 (30%) |
| OCB pattern 5 | Samples | 2/150 (1.3%) | 2/112 (1.8%) | 0/24 (0%) | 2/50 (4%) | 0/50 (0%) | 0/10 (0%) |
| OCB pattern 2 or 3 | Samples | 19/150 (12.7%) | 13/112 (11.6%) | 2/24 (8.3%) | 7/50 (14%) | 3/50 (6%) | 2/10 (20%) |
| OCB pattern 3 or 4 | Samples | 33/150 (22%) | 24/112 (21.4%) | 4/24 (16.7%) | 15/50 (30%) | 6/50 (12%) | 3/10 (30%) |
| OCB pattern 1, 4, or 5 | Samples | 131/150 (87.3%) | 99/112 (88.4%) | 22/24 (91.7%) | 13/50 (86%) | 6/50 (94%) | 3/10 (80%) |
| QIgG > Qlim(IgG) | Samples | 11/133 (8%) | 9/100 (9%) | 1/23 (4%) | 6/47 (12.8%) | 2/44 (4.5%) | 1/8 (12.5%) |
| QIgG, all LPs | - | 3.5 (0.9-23.6; 131) | 3.5 (0.9-23.6; 99) | 3.2 (1.5-14.7; 23) | 4.2 (1.11-23.61; 47) | 2.66 (1.32-14.09; 43) | 4.24 (0.9-4.96; 8) |
| QIgG, if positive | - | 4 (2.3-7; 10) | 4.5 (2.37; 9) | 3.2 (3.2-3.2; 1) | 5.92 (2.26-7.01; 6) | 4.02 (3.57-4.47; 2) | 2.37 (2.37-2.37; 1) |
| IgG IF, all LPs | % IgG(CSF) | 0 (0-53.3; 131) | 0 (0-53.3; 99) | 0 (0-6.8; 23) | 0 (0-53.3; 47) | 0 (0-26.4; 43) | 0 (0-1.1; 8) |
| IgG IF, QIgG positives | % IgG(CSF) | 10.5 (1.13-53.3; 10) | 14.2 (1.1-53.3; 9) | 6.8 (6.8-6.8; 1) | 11.9 (4.5-53.3; 6) | 20.3 (14.2-26.4; 2) | 1.1 (1.1-1.1; 1) |
| IgG IF, > 10% | Samples | 5/131 (3.8%) | 5/99 (5.1%) | 0/23 (0%) | 3/47 (6.4%) | 2/43 (4.7%) | 0/8 (0%) |
| IgG Loc, all LPs | mg/l | 0 (0-25; 127) | 0 (0-25; 96) | 0 (0-2.1; 22) | 0 (0-25; 45) | 0 (0-0.3; 8) | 0 (0-25; 96) |
| IgG Loc, QIgG positives | mg/l | 2.3 (0.29-25; 9) | 4.7 (0.3-25; 8) | 2.1 (2.1-2.1; 1) | 2.3 (1.1-25; 5) | 9.7 (7.9-11.6; 2) | 0.3 (0.3-0.3; 1) |
| IgG CSF, all LPs | mg/l | 33.1 (11-236.1; 129) | 33.3 (11-236.1; 96) | 32.4 (13-182; 22) | 39.8 (11-236.1; 45) | 28.9 (14.6-121; 42) | 27 (17-58; 8) |
| IgG CSF, QIgG positives | mg/l | 38 (22.5-75.7; 9) | 41 (22.5-75.7; 8) | 30.9 (30.9-30.9; 1) | 38 (22.5-75.7; 5) | 49.7 (44-55.4; 2) | 25.8 (25.8-25.8; 1) |
| IgG serum, all LPs | g/l | 9.9 (4-31.8; 127) | 9.9 (4-31.8; 96) | 9.8 (6-12.4; 22) | 9.4 (4-31.8; 45) | 10.2 (5.86-23.9; 42) | 10.84 (4-31; 8) |
| IgG serum, QIgG positives | g/l | 10 (6.3-15.5; 9) | 10.4 (6.3-15.5; 8) | 9.6 (9.6-9.6; 1) | 10 (6.3-11.1; 5) | 12.7 (9.8-15.5; 2) | 10.9 (10.9-10.9; 1) |
| Link index, all | Samples | 13/131 (10%) | 9/99 (9%) | 4/23 (17%) | 7/47 (14.9%) | 2/43 (4.7%) | 0/8 (0%) |
| Link index, if positive | Index | 0.8 (0.7-1.7; 13) | 0.8 (0.7-1.5; 9) | 1.2 (0.7-1.7; 4) | 0.8 (0.7-1.5; 7) | 0.9 (0.8-0.9; 2) | n.a. (n.a.; 0) |
Quotients, indices, concentrations, and fractions are given as median and range
QIgG/A/M CSF/serum IgG/A/M ratio, IgG/A/M IF intrathecally produced IgG/IgA/IgM fraction, IgG/A/M loc locally (intrathecally) produced IgG/A/M, LP lumbar puncture