Table 2.

Gene expression in jejunum after 2 weeks of gavage with CRCE.

Jejunum 2-weeks
Mouse	Human	Function	Vehicle	61.5 mg/kg	184.5 mg/kg	615 mg/kg
Ccl1	CCL1	C-C motif chemokine ligand 1	1.00 ± 0.18	1.69 ± 0.34	1.04 ± 0.23	1.34 ± 0.32
Cxcl1	CXCL1	C-X-C motif chemokine ligand 1	1.00 ± 0.16	2.25 ± 0.85	1.28 ± 0.20	4.69 ± 2.10
Cd14	CD14	Monocyte differentiation antigen CD14	1.00 ± 0.18	1.52 ± 0.35	1.63 ± 0.13A	2.43 ± 0.75
Cxcl2	CXCL2	C-X-C motif chemokine ligand 2	1.00 ± 0.08	0.87 ± 0.16	0.79 ± 0.10	1.30 ± 0.29
Fas**	FAS	Fas cell surface death receptor	1.00 ± 0.03	1.11 ± 0.07	1.27 ± 0.09 A	0.92 ± 0.09
Fasl	FASLG	Fas ligand	1.00 ± 0.14	1.73 ± 0.49	2.63 ± 0.49 A	2.03 ± 0.58
Icam1	ICAM1	Intercellular adhesion molecule 1	1.00 ± 0.05	1.20 ± 0.18	1.48 ± 0.06 A	1.90 ± 0.35 AB
Il1a	IL1A	Interleukin 1 alpha	1.00 ± 0.12	1.11 ± 0.13	1.02 ± 0.07	1.11 ± 0.38
Il1b	IL1B	Interleukin 1 beta	1.00 ± 0.13	1.21 ± 0.27	1.13 ± 0.15	0.52 ± 0.21
Il2	IL2	Interleukin 2	1.00 ± 0.10	0.75 ± 0.42	1.02 ± 0.30	1.10 ± 0.38
Il4	IL4	Interleukin 4	1.00 ± 0.24	1.82 ± 0.79	4.21 ± 1.89	0.70 ± 0.23
Myd88	MYD88	MYD88 innate immune signal transduction adaptor	1.00 ± 0.09	1.12 ± 0.11	1.57 ± 0.15AB	1.67 ± 0.09AB
Tlr2	TLR2	Toll like receptor 2	1.00 ± 0.11	0.98 ± 0.11	0.82 ± 0.03	0.92 ± 0.18
Tlr4	TLR4	Toll like receptor 4	1.00 ± 0.18	3.56 ± 0.43 A	4.77 ± 0.54 AB	7.03 ± 1.12 AB
Tnf	TNF	Tumor necrosis factor	1.00 ± 0.13	1.00 ± 0.43	0.88 ± 0.17	0.19 ± 0.08 A

Data presented at mean fold change from respective vehicle ± SEM (n = 3–6).. Gene expression values between vehicle and each dose were compared with a t-test with Welch’s correction, if needed for unequal variances (^A, significant comparison), and a one-way ANOVA or Kruskal-Wallis test (if failed equal variance test), followed by a multiple comparisons test, using a Bonferroni or Dunn’s correction, of each dose versus vehicle (**, significant ANOVA or Kruskall-Wallis without significant comparison; ^B, significant comparison).