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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Psychopharmacology (Berl). 2020 May 9;237(7):2139–2149. doi: 10.1007/s00213-020-05525-9

Fig 3.

Fig 3.

ACY-738 does not alleviate nociceptive responses in the tail flick assay and hot plate assay. (a) No antinociceptive effect was observed in the hot plate assay in mice treated with ACY-738 pellets for 3 days, (n=8), two-way ANOVA. (b) Rats treated with morphine (5 mg/kg s.c.) show an antinociceptive response in the first two hours of testing ((n=8), one-way ANOVA, followed by Holm—Sidak’s post hoc test, F(4,35)=0.93, ****P<0.0001). (c) No difference in tail flick latency was observed in vehicle treated rats (n=8), one-way ANOVA. (d) No antinociceptive effect was observed in the tail flick assay in groups treated with ACY-738 (10 mg/kg p.o.) twice daily (BID) (n=8), one-way ANOVA. (e) No antinociceptive effect was observed with ACY-738 (10 mg/kg p.o.) once a day (QD) except for a small difference in tail flick latency between one hour and 3 hours of testing (n=8), one-way ANOVA.