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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Psychopharmacology (Berl). 2020 May 9;237(7):2139–2149. doi: 10.1007/s00213-020-05525-9

Table 1.

Pharmacology and pharmacokinetics of ACY-257

ACY-257 Structure HDAC1 IC50 nM HDAC2 IC50 nM HDAC3 IC50 nM HDAC6 IC50 nM Cmax ng/ml T1/2 (h) Plasma AUClast (hr*ng/mL) AUC Brain/AUC Plasma Ratio
graphic file with name nihms-1620791-t0001.jpg 268 530 850 12 1047 8.15 871 (5 mg/kg i.p.) 0.01