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. 2020 May 28;41(7):895–901. doi: 10.1038/s41401-020-0423-5

Fig. 2. pH (low) insertion peptide (pHLIP)-Fc enhanced immunotherapy with natural killer cells.

Fig. 2

a Mechanism by which pHLIP-Fc or pHLIP-mAb activates ADCC. b Comparison of pHLIPs at physiological pH and a weakly acidic pH. Scale bar: 50 µm. c Measurement of CRTAM-positive cells as activated NK cells and the inhibition of tumor growth. Fc/a: Fc fragments from mouse IgG2a; Fc/b: Fc fragments from a mouse. Copyright (2018) John Wiley & Sons, Inc.