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. 2019 Sep 4;41(2):208–217. doi: 10.1038/s41401-019-0298-5

Fig. 5.

Fig. 5

Autophagosome/lysosome inhibitors attenuate degradation of TMEM16A regulated by Endophilin A2. a Effects of concanamycin A (100 nM) on TMEM16A expression modulated by Endophilin A2. n = 6, *P < 0.05 vs. Con and Ad-Endo2 plus concanamycin A. b Effects of Bafilomycin A1 (100 nM) on TMEM16A expression modulated by Endophilin A2. n = 6, *P < 0.05 vs. Con and Ad-Endo2 plus Bafilomycin A1. c Cells cotransfected with RFP-Endophilin A2 and GFP-LC3 plasmids revealed more significant LC3 puncta in comparison with RFP vector and GFP-LC3 group. Statistically significant differences with P-value < 0.05 (*). d Overexpression of Endophilin A2 increased the expression of LC3 and enhanced conversion of LC3 I to LC3 II. n = 6, *P < 0.05 vs. Con