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. 2020 Mar 19;41(8):1041–1048. doi: 10.1038/s41401-020-0394-6

Fig. 3.

Fig. 3

Therapeutic and preventive effects of oltipraz on mechanical allodynia in PINP rats. a No significant change in the PWT was observed after a single intraperitoneal injection of oltipraz at a dose of 10 mg/kg compared with vehicle administration (P > 0.05). However, oltipraz (50 and 100 mg/kg, i.p.) considerably increased the PWT of PINP rats; this change began at 0.5 h, peaked at 1 h, and lasted for ~2 h (**P < 0.01, ***P < 0.001 compared with the vehicle group, n = 6 in each group). b Repeated injections of Olti (100 mg/kg, i.p.) from d 14 to d 18 significantly reversed mechanical allodynia in PINP rats (***P < 0.001 compared with the vehicle group, n = 6 in each group). c The analgesic effect of oltipraz (Olti, 100 mg/kg, i.p.) in PINP was completely abolished by the Nrf2 inhibitor trigonelline (Trig, ***P < 0.001 compared with the vehicle group, ###P < 0.001 compared with the PINP + 100 mg/kg Olti + 20 mg/kg Trig group, n = 6 in each group). d Early treatment with oltipraz (Olti, 100 mg/kg, i.p.) 30 min before the injection of paclitaxel from d 0 to d 6 significantly elevated the PWT of PINP rats on d 7, but not on d 14 or d 21 (*P < 0.05 compared with the vehicle group, n = 6 in each group)