Table 3.
Bootstrap sampling of the three drugs
| Olanzapine | Risperidone | Aripiprazole 1 | Aripiprazole 2 | |
|---|---|---|---|---|
| 1000 | 979 | 999 | 999 | |
| Successful | Successful | Successful | Successful | |
| Bootstrap | Bootstrap | Bootstrap | Bootstrap | |
| Median | Median | Median | Median | |
| (95% CI) | (95% CI) | (95% CI) | (95% CI) | |
| Pharmacodynamics parameters | ||||
| Emax, % | 80.1 (69.30–90.20) | 68 (35.6–85.015) | 45.3 (20.3–90.9) | 23.6 (15.3–34.7) |
| ET50, week | 56.3 (40.1–77.31) | 29.7 (12.68–47.73) | 50.0 (13.0–139) | 37.2 (6.78–28.6) |
| Covariate parameters | ||||
| θ1 on Emax | NA | 32.3 (47.62–16.68) | NA | NA |
| θ2 on Emax | NA | 0.764 (1.14–0.44) | NA | NA |
| θ3 on ET50 | 1.32 (0.94–1.68) | NA | NA | NA |
| θ4 on ET50 | NA | 0.497 (0.03–1.52) | NA | NA |
| θ5 on ET50 | 2.48 (1.71–3.23) | NA | NA | NA |
| Variability parameters | ||||
| η (Emax), % | 21.85 (12.70–30.60) | 20.2 (0.3–92.54) | 57.1 (27.2–76.7) | 57.8 (25.0–79.2) |
| η (ET50), % | 118.3 (94.69–141.8) | 122.5 (60.28–156.2) | 61.6 (0.30–117) | − |
| ε, % | 7.868 (5.97–10.05) | 8.905 (5.65–12.89) | 12.8 (7.40–18.7) | 10.7 (8.15–16.6) |
Emax maximal effect of drug, ET50 time to achieve 50% of Emax, θ on Emax or ET50 effect of the parameter θ used to correct the effect on Emax or ET50, η interstudy variability of pharmacodynamic parameter, ε residual error, NA parameter is not estimated, RSE relative standard error. θ1, Episode; θ2, PANSS total score; θ3, Onset frequency; θ4, Course (month); θ5, General psychopathology score. Aripiprazole 1, original data set; Aripiprazole 2, outliers remove