Fig. 2.

Expression of podoplanin (PDPN) in streptozotocin (STZ)-induced diabetic mice. Kidney histology and expression of PDPN were documented with immunohistochemical staining (magnification ×400). PDPN in the glomerulus stained brown, and the brown area of the STZ group was significantly smaller than that of the control group 8 weeks after STZ injection (a). To quantify the expression of PDPN, the integrated optical density (IOD) of the brown region in the picture was selected to represent the relative expression of PDPN (b). The data are expressed as the mean ± SEM. *P < 0.05, **P < 0.01 compared to the control group