a The average tumor volume in control mice (n = 8) and NLE-treated mice (n = 8, 10 mg/kg/d, i.p.) ~4 weeks after A549 cell injection. b After treatment for 3 weeks, the mice were sacrificed, their tumors were photographed, and differences in tumor weight were determined. c Mouse body weights. d H&E staining of liver, spleen and kidney biopsy samples, 200 ×, bar = 50 µm. *P < 0.05, **P < 0.01, compared with the vehicle-treated control group.