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. 2020 May 4;41(7):959–969. doi: 10.1038/s41401-020-0415-5

Fig. 1. Activation of antigen-specific T cells by DCs.

Fig. 1

Antigen-pulsed DCs home from peripheral tissues to lymphoid organs, where they present processed antigens to encountered T cells for specific recognition. Full activation of T cells is collectively governed by three different signals, provided by TCR recognition of peptide-MHC complex, co-stimulation, and tonic cytokines signaling.