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. 2020 May 4;41(7):959–969. doi: 10.1038/s41401-020-0415-5

Fig. 2. Schema of vaccination with ex vivo pulsed DCs against cancer.

Fig. 2

DCs are typically generated from autologous CD14+ monocytes, HSPCs, and differentiated into immature DCs in the presence of various stimuli. Also, DCs can be derived from fibroblasts by transdifferentiation, and from iPSCs. In addition, existing DCs are isolated from patients. After maturation and pulsing with antigen of diverse forms, mature DCs are administered back into the patients via various routes. i.n. intranodally. i.d. intradermally. i.v. intravenously.