Fig. 7.

NADPH activated the AMPK-mTOR pathway in myocardial ischemia/reperfusion injury. a, b Neonatal rat cardiomyocytes were treated as described in Fig. 4. N(L) = 60 nM, N(H) = 500 nM. a NADPH increased the phosphorylation of AMPK in cardiomyocytes. b NADPH reduced the phosphorylation of mTOR in cardiomyocytes. n = 3 independent cultures. c, d Rats were treated as described in Fig. 5. c NADPH increased the phosphorylation of AMPK in the myocardium. d NADPH reduced the phosphorylation of mTOR in the myocardium. n = 6 rats. The bar represents mean ± SD, ^*P < 0.05, ^**P < 0.01 compared with the OGD/R group or I/R group