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. 2020 Jan 14;41(6):800–812. doi: 10.1038/s41401-019-0337-2

Fig. 2. Histopathological evaluation of the spleen and joints in CIA rats and the effects of IgD-Fc-Ig.

Fig. 2

a The effects of IgD-Fc-Ig on histopathological changes in the spleen. In normal rats, → shows red pulp and ↓ shows white pulp. In CIA rats, → shows germinal centers, ↓ shows lymphoid follicular hyperplasia, ↙ shows periarteriolar lymphoid sheaths, and ↘ shows red medullary congestion. b Comparison of the pathological changes in the spleen in different groups. c The effects of IgD-Fc-Ig on histopathological changes in the joints. In normal rats, ↓ shows the synovial membrane. In CIA rats, ↑ shows synovial hyperplasia, ↓ shows inflammatory cell infiltration, ← shows vascular pannus, and ↖ shows cartilage damage. d Comparison of the pathological changes in joints in different groups. #P < 0.05, ##P < 0.01 vs CIA (n = 6).