Fig. 3.

The conditional Kiss1 knockout (KO) mice showed suppression of gonadotropin secretion. Plasma luteinizing hormone (LH, A) and follicle-stimulating hormone (FSH, B) levels of the conditional Kiss1 KO mice and Cre-negative Kiss1^fl/fl controls. Values are indicated as mean ± SEM. Note that plasma LH levels were undetectable in all conditional Kiss1 KO mice and expressed as the least detectable concentration of LH (0.156 ng/ml). Numbers in or on each column indicate the number of animals used. * P < 0.05 between the conditional Kiss1 KO mice and Cre-negative Kiss1^fl/fl controls (Welch’s-t test).