Figure 1.
Acoustically-driven changes in mature synapses. A, Experimental timeline for acoustic manipulations. All cells were recorded after P57. Ctrl mice were raised under normal (Norm) sound conditions. Occyoung mice were occluded at P14 until recordings. Occold mice were occluded at P51 until recordings. Nryoung mice were noise-reared at P12 until recordings. Nrold mice were noise-reared at P51 until recordings. Rec (recovery) mice were noise-reared between P12 and P51, then held in normal sound conditions until recordings. B, Representative EPSCs from mice raised in the sound conditions in A. A single presynaptic ANF was isolated and stimulated in pairs with a 3 ms interval. Vertical bars = 1 nA. C–E, PPR (C), EPSC1 amplitude (D), and decay τ (E) for different treatment groups in A. Error bars indicate mean ± SEM. Horizontal markers represent individual experiments (7-12 cells each condition). *p < 0.05, NS = not significant (p > 0.05).