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The frequency of large spines increased with age in WT, but not A53T-BAC-SNCA, mice. A, The distribution of large spines in WT mice was significantly different between 6 and 22 months of age (*p = 0.01, Kolmogorov–Smirnov test). B, In contrast, the distribution of large spines was not significantly different between 6 and 22 months of age in A53T-BAC-SNCA mice (p = 0.86, Kolmogorov–Smirnov test).
