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. 2020 Aug 27;7(4):ENEURO.0072-20.2020. doi: 10.1523/ENEURO.0072-20.2020

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Copyright © 2020 Parajuli et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Localization of phosphorylated α-synuclein in a subset of presynaptic terminals in A53T-BAC-SNCA mice. A–D, TEM images of pre-embedding immunogold-labeled samples from A53T-BAC-SNCA mice at 1 (A), 3 (B), 6 (C), and 22 (D) months. Note that the immunogold particles, indicating phosphorylated α-synuclein, were predominantly localized to presynaptic terminals. Immunogold particles were often seen in clusters. E, A low-magnification image from an A53T-BAC-SNCA mouse at 3 months of age demonstrates that a subset of large presynaptic terminals was immunopositive for phosphorylated α-synuclein. s: spine; T: presynaptic terminals with immunoreactivity for phosphorylated α-synuclein; t: presynaptic terminals lacking immunoreactivity for phosphorylated α-synuclein. Scale bars: 500 nm.