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. 2020 Aug 1;48(15):8529–8544. doi: 10.1093/nar/gkaa642

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Effect of nucleotide variations on MEF2B binding. (A, B) Comparison of relative affinities for each of the central four nucleotide positions, considering all sequences based on the CTAW₄TAG reference motif. (A) Affinity logos generated based on the reference sequence show effects of single-nucleotide substitutions on a MEF2B target site. (B) Mean average relative affinity based on each nucleotide substitution. (C, D) Box plots showing changes in relative binding affinities for (C) A→ G and A→C substitutions at each position (−2, −1, +1, +2) or (D) for AAAA to alternative indicated 4-mers. (E, F) Bar plots showing numbers of specific sequence hits (as indicated) in ChIP-seq peaks.