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A circularization model of mitochondrial mRNA stabilization pathway in trypanosomes. We propose that mRNA stability is determined by PPsome and polyadenylation complexes that sequester 5′ and 3′ termini, respectively. It appears that distinct modalities within RNA editing substrate binding complex (RESC) interact with these end-bound particles to facilitate mRNA circularization and resistance to 3′-5′ degradation by the MPsome.
