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. 2020 Jul 7;48(15):8782–8795. doi: 10.1093/nar/gkaa578

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Analysis of positively charged surface residues of rnGLD-2. (A) The electrostatic surface potential of rnGLD-2. Some positively charged residues are specified. Two positively charged patches and the catalytic cleft are indicated. (B) The surface conservation plots of rnGLD-2 within the GLD-2 family (left) and among other NTases including MTPAP, Cid1, TUT4 and TUT7 (right). (C) PAP activity of rnGLD-2 with mutations of positively charged surface residues as in A. (D) EMSA results showing the substrate affinity of rnGLD-2 with mutations of positively charged surface residues as in A.