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. 2020 Jun 26;48(15):e85. doi: 10.1093/nar/gkaa506

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — scIGANs improves time-course scRNA-seq data analysis and reconstructing differentiation trajectory. (A) The time points of scRNA-seq sampling along with the differentiation from the pluripotent state (H1 cells) through mesendoderm to definitive endoderm cells (DEC). (B, C) The trajectories reconstructed by monocle3 from the raw (C) and scIGANs imputed (D) scRNA-seq data. (D, E) The expression dynamics of two pluripotent (left) and DEC (right) signature genes are shown in the order of the pseudotime. The plots of all other imputation methods are provided in Supplementary Figure S8. Also see Supplementary Figure S8.