FIG 1.

Schematic presentation of BVD structure and the biosynthetic gene cluster. (A) Common structure of BVDs. The analogs with different amino acid residues l-AA2, l-AA3, and d-AA4 as well as the letters X, Y, Z, n, and R can be referred to in Table S1 in the supplemental material. (B) Conservative relationship of the gene clusters responsible for the biosynthesis of BVDs in different fungi. The genes labeled in the same color show orthologous relationships. (C) Similarity analysis of the clustered genes in three insect pathogens. *, identity at the amino acid level compared with the homologs of B. bassiana.