Table 1.
HDACs expression exhibited different roles in overall survival of IDC patients (n = 16l)
| Univariate | Multivariate | Multivariate | Multivariate | Multivariate | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Clinicopathological characteristics | HR(95%CI) | P‐value | HR(95%CI) | P‐value | HR(95%CI) | P‐value | HR (95%CI) | P‐value | HR (95%CI) | P |
| Age, years | ||||||||||
| <48 | 1 | / | / | / | / | / | / | / | / | |
| ≥48 | 1.398(0.892‐2.192) | 0.144 | / | / | / | / | / | / | / | / |
| Tumor size † , cm | 0.000 * | 0.001 * | 0.004 * | 0.004 * | 0.002 * | |||||
| ≤2 | 1 | 1 | 1 | 1 | 1 | |||||
| 2‐5 | 3.432(1.363‐8.640) | 0.009 * | 4.918(1.165‐20.752) | 0.030 * | 3.942(0.937‐16.581) | 0.061 | 4.190(1.000‐17.565) | 0.050 | 4.105(0.981‐17.188) | 0.053 |
| >5 | 10.957(4.141‐28.993) | 0.000 * | 13.005(2.753‐61.445) | 0.001 * | 9.130(1.966‐42.403) | 0.005 * | 9.614(2.077‐44.510) | 0.004 * | 9.998(2.177‐45.912) | 0.003 * |
| Histological grade † | 0.000 * | 0.000 * | 0.000 * | 0.000 * | 0.000 * | |||||
| I | 1 | 1 | 1 | 1 | 1 | |||||
| II | 7.343(1.011‐53.346) | 0.049 * | 3.966(0.518‐30.345) | 0.184 | 3.283(0.433‐24.921) | 0.250 | 3.578(0.472‐27.109) | 0.217 | 3.076(0.403‐23.476) | 0.279 |
| III | 32.775(4.422‐242.943) | 0.001 * | 13.491(1.686‐107.931) | 0.014 * | 10.961(1.377‐87.253) | 0.024 * | 11.852(1.497‐93.838) | 0.019 * | 10.884(1.363‐86.921) | 0.024 * |
| Lymph node status † | ||||||||||
| Negative | 1 | 1 | 1 | 1 | 1 | |||||
| Positive | 1.952(1.182‐3.223) | 0.009 * | 2.092(1.163‐3.764) | 0.014 * | 1.781(0.985‐3.218) | 0.056 | 1.697(0.936‐3.079) | 0.082 | 1.572(0.862‐2.865) | 0.140 |
| ER status † | ||||||||||
| Negative | 1 | 1 | 1 | 1 | 1 | |||||
| Positive | 0.303(0.190‐0.483) | 0.000 * | 0.875(0.459‐1.669) | 0.685 | 0.803(0.431‐1.498) | 0.491 | 0.953(0.496‐1.833) | 0.886 | 0.891(0.465‐1.705) | 0.727 |
| PR status † | ||||||||||
| Negative | 1 | 1 | 1 | 1 | 1 | |||||
| Positive | 0.341(0.211‐0.550) | 0.000 * | 0.515(0.269‐0.989) | 0.046 * | 0.489(0.264‐0.906) | 0.023 * | 0.455(0.239‐0.868) | 0.017 * | 0.483(0.251‐0.930) | 0.029 * |
| HER2 status † | ||||||||||
| Negative | 1 | / | / | / | / | / | / | / | / | |
| Positive | 1.465(0.921‐2.332) | 0.107 | / | / | / | / | / | / | / | / |
| HDAC1 status † | ||||||||||
| Low | 1 | 1 | ||||||||
| High | 2.540(1.549‐4.165) | 0.000 * | 2.799(1.652‐4.741) | 0.000 * | ||||||
| HDAC2 status † | ||||||||||
| Low | 1 | 1 | ||||||||
| High | 1.874(1.111‐3.162) | 0.019 * | 1.823(1.059‐3.136) | 0.030 * | ||||||
| HDAC3 status † (nucleus) | ||||||||||
| Low | 1 | 1 | ||||||||
| High | 2.043(1.217‐3.430) | 0.007 * | 1.645(0.941‐2.876) | 0.081 | ||||||
| HDAC3 status † (cytoplasm) | ||||||||||
| Low | 1 | 1 | ||||||||
| High | 2.406(1.403‐4.126) | 0.001 * | 1.948(1.089‐3.486) | 0.025 * | ||||||
†
Some data were missing.
*
Indicates statistical significance (P < 0.05).
P‐value was calculated by Cox regression analysis.