. 2020 Jul 20;11(9):2493–2505. doi: 10.1111/1759-7714.13561

Table 2.

Relationship between clinicopathological characteristics and HDACs expression in IDC patients (n = 139)

		HDAC3 (cytoplasm), n				HDAC3 (nucleus), n				HDAC1, n				HDAC2, n
Clinicopathological characteristics	Cases	Low	High	r _s or χ ² ^‡	P ^§	Low	High	r _s or χ ² ^‡	P ^§	Low	High	r _s or χ ² ^‡	P ^§	Low	High	r _s or χ ² ^‡	P ^§
Age, years				‐0.022	0.799			0.092	0.280			‐0.057	0.508			0.214	0.01 ^*
<48	57	42	15			45	12			38	19			49	8
≥48	82	62	20			58	24			59	23			55	27
Tumor size ^† , cm				0.144	0.093			0.144	0.094			0.022	0.798			0.087	0.311
≤2	21	18	3			16	5			14	7			16	5
2‐5	91	68	23			71	20			65	26			70	21
>5	25	16	9			14	11			16	9			16	9
Histological grade ^†			0.203	0.018 ^*		0.078	0.366			0.081	0.348v		0.079	0.362
I	13	12	1			9	4			10	3			10	3
II	97	74	23			75	22			68	29			74	23
III	27	16	11			17	10			17	10			18	9
Lymph node status ^†				0.178	0.036 ^*			0.155	0.069			‐0.006	0.948			0.006	0.940
Negative	52	44	8			43	9			36	16			39	13
Positive	86	59	27			59	27			60	26			64	22
ER status ^†				‐0.186	0.029 ^*			‐0.173	0.042 ^*			‐0.066	0.445			0.030	0.724
Negative	44	28	16			28	16			29	15			34	10
Positive	94	76	18			75	19			68	26			70	24
PR status ^†				‐0.092	0.283			‐0.043	0.619			‐0.114	0.183			‐0.024	0.775
Negative	62	44	18			15	17			40	22			46	16
Positive	76	60	16			58	18			57	19			58	18
HER2 status ^†				0.077	0.371			0.064	0.457			‐0.042	0.625			0.112	0.191
Negative	90	70	20			69	21			62	28			71	19
Positive	48	34	14			34	14			35	13			33	15
Brain metastasis				0.279	0.001 ^*			0.158	0.064			0.021	0.806			0.061	0.476
No	98	81	17			77	21			69	29			75	23
Yes	41	23	18			26	15			28	13			29	12
Molecular subtypes ^†				7.670 ^¶	0.022 ^* ^, ^¶			4.453	0.108			1.859	0.395			0.699	0.705
Luminal	98	80	18			78	20			72	26			72	26
HER2 overexpression	14	7	7			8	6			8	6			11	3
Triple negative	26	17	9			17	9			17	9			21	5

^{^†}

Some data were missing.

^{^‡}

r _s for age, tumor size, histological grade, lymph node status, ER, PR, HER2, and brain metastasis; χ ² for molecular subtypes.

^{^§}

P‐value was calculated by Spearman's rank correlation test for age, tumor size, histological grade, lymph node status, ER, PR, HER2, and brain metastasis; P‐value was calculated by χ ² test for molecular subtypes.

^{^¶}

HDAC3 (cytoplasm): Luminal vs. HER2 overexpression: P = 0.021, χ ² = 5.363; Luminal versus Triple negative: P = 0.074, χ ² = 3.185; HER2 overexpression versus Triple negative: P = 0.343, χ ² = 0.897.

^{^*}

Indicates statistical significance (P < 0.05).