Table 3.
HDACs expression exhibited different roles in the onset of brain metastasis of IDC patients (n = 161)
| Univariate | Multivariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| Clinicopathological characteristics | HR (95% CI) | P‐value | HR (95% CI) | P‐value | HR (95% CI) | P‐value |
| Age, years | ||||||
| <48 | 1 | / | / | / | / | |
| ≥48 | 0.760(0.463‐1.250) | 0.280 | / | / | / | / |
| Tumor size † , cm | 0.000 * | 0.006 * | 0.001 * | |||
| ≤2 | 1 | 1 | 1 | |||
| 2‐5 | 1.409(0.647‐3.070) | 0.388 | 2.576(0.599‐11.086) | 0.204 | 2.550(0.597‐10.900) | 0.207 |
| >5 | 5.159(2.220‐11.986) | 0.000 * | 7.317(1.569‐34.120) | 0.011 * | 8.975(1.953‐41.239) | 0.005 * |
| Lymph node status * | ||||||
| Negative | 1 | / | / | / | / | |
| Positive | 1.466(0.858‐2.504) | 0.161 | / | / | / | / |
| ER status † | ||||||
| Negative | 1 | 1 | 1 | |||
| Positive | 0.279(0.165‐0.471) | 0.000 * | 0.499(0.216‐1.153) | 0.104 | 0.541(0.231‐1.266) | 0.157 |
| PR status † | ||||||
| Negative | 1 | 1 | 1 | |||
| Positive | 0.360(0.211‐0.614) | 0.000 * | 0.448(0.190‐1.054) | 0.066 | 0.417(0.164‐1.058) | 0.066 |
| HER2 status † | ||||||
| Negative | 1 | 1 | 1 | |||
| Positive | 1.655(0.984‐2.783) | 0.057 | 1.264(0.642‐2.487) | 0.497 | 1.045(0.521‐2.093) | 0.902 |
| HDAC1 status † | ||||||
| Low | 1 | |||||
| High | 1.370(0.705‐2.661) | 0.353 | ||||
| HDAC2 status † | ||||||
| Low | 1 | |||||
| High | 1.555(0.793‐3.051) | 0.199 | ||||
| HDAC3 status † (nucleus) | ||||||
| Low | 1 | 1 | ||||
| High | 2.305(1.219‐4.360) | 0.010 * | 1.712(0.843‐3.477) | 0.137 | ||
| HDAC3 status † (cytoplasm) | ||||||
| Low | 1 | 1 | ||||
| High | 3.932(2.112‐7.322) | 0.000 * | 3.386(1.724‐6.650) | 0.000 * | ||
†
Some data were missing.
*
Indicates statistical significance (P < 0.05).
P‐value was calculated by Cox regression analysis.