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. 2020 Aug 3;11(9):2630–2638. doi: 10.1111/1759-7714.13593

Figure 1.

Figure 1

Effect of mAb NJ001 on lung adenocarcinoma cell motility and invasiveness. (a) Representative images of SPC‐A1 cell motility under treatment with 0, 50, 100 or 150 ng/μL NJ001 at 0 and 48 hours, respectively. Scale bar: 100 μm. (b) Cell motility was quantified by measuring the distance traveled by the cells between the two boundaries of the acellular area; the results are expressed as a ratio to cells treated with 0 ng/μL NJ001 (controls). (c) Representative images of SPC‐A1 and A549 cell invasiveness and metastatic ability after treatment with 0, 50, 100 or 150 ng/μL NJ001 for 48 hours. Scale bar: 100 μm. (d, e) Cell invasiveness of (d) SPC‐A1; and (e) A549 cells was quantified by counting cells that passed through the Matrigel membrane, using a light microscope (×200). Each experiment was performed three times. Data are expressed as the means ± s.d. *P < 0.05, **P < 0.01, compared with 0 ng/μL NJ001.