Table 1.
Characteristics of DLL3‐positive and DLL3‐negative pulmonary LCNEC patients
| Factor | DLL3‐positive (n = 26) | DLL3‐negative (n = 44) | P‐value |
|---|---|---|---|
| Mean age, range (years) | 65.6 (50–78) | 71.1 (45–84) | <0.01 |
| Sex | |||
| Male | 21 (81%) | 39 (89%) | 0.37 |
| Female | 5 (19%) | 5 (11%) | |
| Smoking status | |||
| Former or current | 24 (92%) | 41 (93%) | 0.49 |
| Never smoked | 2 (8%) | 3 (7%) | |
| Lung function | |||
| Mean FEV1.0% | 74.0% | 66.6% | <0.01 |
| Surgical procedure | |||
| Lobectomy | 22 (85%) | 34 (77%) | 0.45 |
| Sublobar resection | 4 (15%) | 10 (23%) | |
| Adjuvant chemotherapy | |||
| Performed | 12 (46%) | 11 (25%) | 0.07 |
| Pure or combined | |||
| Pure LCNEC | 26 (100%) | 39 (89%) | 0.07 |
| Combined LCNEC | 0 (0%) | 5 (11%) | |
| Pathological stage | |||
| IA | 5 (19%) | 16 (36%) | 0.11 |
| IB | 10 (38%) | 10 (22%) | |
| IIA | 4 (15%) | 5 (11%) | |
| IIB | 0 (0%) | 6 (14%) | |
| IIIA | 6 (23%) | 7 (16%) | |
| IIIB | 1 (4%) | 0 (0%) | |
| Pathological tumor size (mm) | |||
| Mean | 38.2 | 35.6 | 0.59 |
| Lymph node metastasis | |||
| pN 0 | 18 (69%) | 33 (75%) | 0.60 |
| pN 1–2 | 8 (31%) | 11 (25%) | |
| Pleural invasion | |||
| (−) | 14 (54%) | 27 (61%) | 0.54 |
| (+) | 12 (46%) | 17 (39%) | |
| Vascular invasion | |||
| (−) | 5 (19%) | 15 (34%) | 0.18 |
| (+) | 21 (81%) | 29 (66%) | |
| Lymphatic permeation | |||
| (−) | 4 (15%) | 22 (50%) | <0.01 |
| (+) | 22 (85%) | 22 (50%) | |