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(a) Combined index (CI) of osimertinib and palbociclib (
) Measured value; (b) Inhibitory effect of osimertinib, palbociclib and combination in H1975OR cells (
) Osimertinib, (
) CDK4/6 inhibitor, and (
) combination; (c) Crystal violet staining; (d, e) The bar graph shows the effect of osimertinib, palbociclib and combination on H1975OR proliferation ([c] Osi 2.5 μM, Palbociclib 1.25 μM; Combi 2:1, P < 0.05; [d] Osi 1.25 µM, Palbociclib 1.25 µM; Combi 1:1, P < 0.05).
