Fig. 3. Immune profiles of MTBK_24820-specific cytokine/chemokine responses in diagnostic groups. (A) IFN-γ, (B) CXCL10, (C) IL-6, and (D) TNF-α were measured in response to MTBK_24820 in active TB (n=52), LTBI (n=31), and healthy control (n=65) groups. (B and C) Significantly higher CXCL10 and IL-6 responses were also found in active TB patients than in the healthy controls in response to MTBK_24820. Disease status (active TB vs. LTBI) was differentiated by MTBK_24820-specific CXCL10. (A and D) IFN-γ and TNF-α responses were not significantly changed in the three groups, compared with other cytokines. The horizontal lines represent medians (^*p<0.05, ^**p<0.01, ^***p<0.001; Kruskal-Wallis and Dunn's multiple comparison tests). HC, healthy control; LTBI, latent TB infection; TB, tuberculosis; IFN, interferon; IL, interleukin; CXCL10, C-X-C motif chemokine; TNF, tumor necrosis factor.