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. 2020 Jul 29;39(36):5876–5887. doi: 10.1038/s41388-020-01399-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Relative expression of PIERCE1 transcripts in large-cell carcinoma (Large) and lung adenocarcinoma (LA) from the Hou lung database (a), squamous-cell carcinoma (SCC) and LA from TCGA database (b), KRAS wild type (WT) and mutant type (Mut) of LA from Bild lung (c) and Ding lung (d) databases, and WT and mutant KRAS lung cancer, and normal lung cell lines (e). KRAS genotype was indicated on the bottom of samples and cell line names. For panel a–d, Oncomine database of Hou, TCGA, Bild, and Ding were analyzed. Colony forming assays of NIH3T3 cells 14 days after transfection for overexpression (f) or knockdown (g) of PIERCE1. Colonies were formed by overexpression of mutant HRAS (HRAS^V12). Representative images and average numbers of colonies were shown in the upper and the lower panel, respectively. Error bars are ±SD *P < 0.05; **P < 0.01; ***P < 0.0001.