Table 3.

Determinants of QoL after CRS with HIPEC

Determinant	Result	References
Age (years)	Younger age leads to a quicker recovery of QoL	Kopanakis32,Macrí 33
Sex	Female sex is associated with lower QoL and lower emotional health	Albertsmeier27, Kopanakis32
Primary tumor site	Ovarian carcinomas show slower recover of QoL Colon and gastric cancer show lower QoL but higher emotional health	Albertsmeier27, Macrí33
Malignant ascites	Patients with malignant ascites show lower baseline scores of QoL but, after operation, immediate increase of QoL Patients without malignant ascites experience a decrease of QoL at 3 months, after which recovery begins	McQuellon35
Prolonged operation time	Longer duration of surgery is associated with diminished QoL	Chia22,Passot36
PCI	Patients with higher PCI suffer from greater decrease in QoL One study did not find a difference in QoL in patients with high or low PCI	Chia22,Kopanakis32,Passot36,Albertsmeier27
CC score	Patients with higher CC score experience higher decrease of QoL	Chia22,Kopanakis32,Macrí33,Passot36
Type of bowel resection	Type of bowel resection does not influence QoL Social function scores are lower in patients with lower anterior resection	Bayat39
Adjuvant chemotherapy	Patients who receive adjuvant chemotherapy show lower QoL after CRS + HIPEC	Macrí33,Chia22
Complication	Patients who experienced complications show slower recovery of QoL	Tuttle38,Hamilton29
Presence of Stoma	Presence of a stoma is negatively associated with QoL	Chia22,Kopanaki32,Passot36
Recurrence	Recurrence within 1 year leads to a lower QoL	Chia22,Passot36

CC score Completeness of Cytoreduction Score, CRS cytoreductive surgery, HIPEC hyperthermic intraperitoneal chemotherapy, PCI Peritoneal Cancer Index, QoL quality of life