Table 2.
Clinico-pathological and molecular features in the treatment-naive group
| HPV-positive | HPV-negative | p value (Χ2 test) | HPV16 viral load (log10 transformed) | p value (Mann-Whitney U test) | |
|---|---|---|---|---|---|
| Age (years), median (range) | 64.3 (46.8–88) | 60 (59.2–69.1) | 2.13 | ||
| Sex | |||||
| Male | 2 (67%) | 1 (33%) | 1.87 | ||
| Female | 8 (80%) | 2 (20%) | p = 0.63 | 2.14 | p = 0.89 |
| Tumor classification | |||||
| T1 + T2 | 2 (50%) | 2 (50%) | 1.93 | ||
| T3 + T4 | 8 (89%) | 1 (11%) | p = 0.12 | 2.14 | p = 1.0 |
| Lymph node involvement | |||||
| Negative | 6 (75%) | 2 (25%) | 2.21 | ||
| Positive | 4 (80%) | 1 (20%) | p = 0.84 | 2.14 | p = 0.74 |
| Smoking statusa | |||||
| Nonsmoker | 4 (100%) | 0 | 3.04 | ||
| Ever smoker | 6 (67%) | 3 (33%) | p = 0.18 | 1.14 | p = 0.03 |
| p16 expression | |||||
| Negative | 1 (50%) | 1 (50%) | 1.14 | ||
| Positive | 9 (82%) | 2 (18%) | p = 0.32 | 2.22 | p = 1.0 |
| p53 staining pattern | |||||
| Negative | 2 (100%) | 0 | 1.63 | ||
| Scattered | 4 (100%) | 0 | 2.63 | ||
| Diffuse | 4 (57%) | 3 (43%) | p = 0.18 (negative vs. scattered vs. diffuse) | 0.76 | p = 0.22 (Kruskal-Wallis test) (negative vs. scattered vs. diffuse) |
| Smoking history (pack-yearsb), median (N) | 25.5 pack-years (4) | 15.0 pack-years (3) | p = 0.85 | ||
aData on smoking were available in only 27 cases, while data on smoking duration and number of cigarettes smoked were available for 13/16 smokers
bPack-year is calculated by multiplying the number of packs of cigarettes smoked per day by the number of years the person has smoked