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. 2019 May 4;26(4):2023–2033. doi: 10.1007/s12253-019-00663-8

Table 3.

The implication of histone acetylase inhibitors(HDACis) in CRC treatment

Class Specificity HDACis Experiment design Effect Reference
Hydroxamic acids Class I, II Trichostatin A (TSA) CRC cell lines Inhibit CRC cells growth [87]
Vorinostat (SAHA) Mouse model Inhibit the growth of colon tumors in nude mice [88]
CRC cell lines Anti-proliferative in CRC cell lines [89]
Panobistat CRC cell lines HCC cell lines Anti-angiogenic Reduce proliferation [98]
Belinostat CRC cell lines Induce CRC cell apoptosis [97]
Short-chain fatty acids Class I Butyrate CRC cell lines Inhibit CRC cell migration and invasion [93]
Valproic acid (VPA) CRC cell lines Inhibit the growth of CRC cell lines with cell cycle arrest [90]
Benzamides Class I Entinostat (MS-275) CRC cell lines mouse model Anti-proliferative effects [94]
Benzoic acid Dihydroxy benzoic acid Colon cell lines Induce cancer cell death [96]
Cyclic peptides Class I, II Romidepsin (FK228) CRC cell lines Anti-tumor activity [91]