Figure 3.

GO annotation analysis for the target genes of the top 10 most downregulated miRNAs. (A) Baseline analysis and (B) delta analysis. Category 1, we divided BC patients into two groups with clinical integrity, clinical concordance versus discordance. Clinical concordance was defined as a group of patients who were pCR/not relapsed and non-pCR/relapsed, according to NAC. On the other hand, clinical discordance was defined as a group of patients who were pCR/relapsed and non-pCR/not relapsed, according to NAC. Category 2, we divided NAC treated BC patients according to whether they relapsed in the group having pCR. Two microarray data sets GSE32603 and GSE87455 were downloaded from the GEO database. The data were processed by unpaired t-test (P<0.05, |log2FC| >0.17). Abbreviations: GO, Gene Ontology. BC, breast cancer; pCR, pathological complete response; NAC, neoadjuvant chemotherapy; GEO, Gene Expression Omnibus.