Table 3.
Identification of top 25 hub nodes according to degree related with the top 10 mRNA with more changes in each category of each NAC cohort in Baseline
| Category 1 | Category 2 | ||||||
|---|---|---|---|---|---|---|---|
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| GSE32603 | GSE87455 | GSE32603 | GSE87455 | ||||
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| Gene Symbol | Degree | Gene Symbol | Degree | Gene Symbol | Degree | Gene Symbol | Degree |
| SRC | 43 | GAPDH | 305 | UBB | 50 | TP53 | 37 |
| HSP90AA1 | 41 | HSPA8 | 260 | TP53 | 44 | EGFR | 31 |
| CSK | 33 | EEF2 | 236 | UBD | 37 | HSP90AA1 | 30 |
| JUN | 29 | HSP90AA1 | 225 | EGFR | 36 | MUC1 | 25 |
| FYN | 26 | RPS3 | 225 | CTNNB1 | 31 | ERBB2 | 25 |
| SHC1 | 24 | RPL4 | 222 | CDH2 | 30 | SRC | 25 |
| YWHAE | 23 | RPLP0 | 215 | SKP1 | 26 | ESR1 | 25 |
| PXN | 22 | RPS2 | 214 | UBQLN1 | 26 | JUN | 23 |
| UBE2I | 19 | EEF1A1 | 212 | ITCH | 25 | HSPA4 | 21 |
| HIST1H4F | 18 | EIF4A3 | 211 | PSMD4 | 25 | CTNNB1 | 21 |
| AKT2 | 18 | RPS16 | 208 | EEF1A1 | 24 | APP | 21 |
| IKBKG | 18 | RPS20 | 207 | WWP1 | 22 | ABL1 | 20 |
| EIF4E | 18 | CCT2 | 205 | NEDD4 | 22 | GRB2 | 19 |
| PARP1 | 18 | EPRS | 202 | NEDD4L | 22 | SRSF7 | 19 |
| PTK2 | 17 | RPS6 | 201 | PSMA6 | 21 | SRSF11 | 19 |
| CAV1 | 17 | GNB2L1 | 201 | RPL8 | 20 | U2AF2 | 18 |
| EEF1A1 | 16 | RPS14 | 201 | PSMC3 | 20 | TOP1 | 17 |
| PDPK1 | 16 | RPS9 | 200 | CDC34 | 19 | SRSF5 | 16 |
| ZAP70 | 16 | NOP56 | 200 | RPS16 | 19 | SRSF3 | 15 |
| IGF1R | 16 | RPL8 | 198 | CCNA2 | 19 | GSK3B | 15 |
| H1F0 | 16 | RPL5 | 196 | TSG101 | 18 | SAP18 | 15 |
| HNRNPK | 15 | RPL7 | 196 | RPL3 | 17 | TBP | 15 |
| ILK | 15 | HSPA4 | 194 | ERBB2 | 17 | PPARG | 15 |
| HSPA5 | 15 | HNRNPA1 | 194 | APP | 17 | TRA2B | 14 |
| TRAT1 | 15 | RPL11 | 194 | HGS | 16 | PRKCD | 14 |
Abbreviations: NAC, neoadjuvant chemotherapy.