Table 2.

A summary of the application of brain tumour organoids

Year/Author	Basic research	Drug screening	Immune-therapy	Chemotherapy/Radiotherapy	Biobank
Hubert et al. 2016 [41]	Exploration of microenvironmental influences and CSC biology	No reported	No	Yes	No reported
Ogawa et al. 2018 [45]	Model for tumour formation; Platform for tumour cell transplantation	No reported	No	No reported	No reported
Bian et al. 2018 [44]	Studying tumour biology	Afatinib, erlotinib, gefitinib, canertibib, pelitinib	No	No reported	No reported
Da Silva et al. 2018 [48]	Modelling the process of GBM invasion	No reported	No	No reported	No reported
Linkous et al. 2019 [46]	GBM biology, tumour microtubes	TMZ, BCNU	No	Yes	No reported
Krieger 2019 [49]	Studying GBM invasion and transcriptional heterogeneity	Yes	No	Yes	No reported
Jacob et al. 2020 [43]	Exploration of cellular heterogeneity, GBO engraftment and infiltration	TMZ, gefitinib, trametinib, everolimus	CAR-T	Yes	Yes
Ballabio et al. 2020 [47]	Studying medulloblastoma biology	Tazemetostat	No	No reported	No reported