Fig. 3.
Kinetic analysis of cocaine-induced inhibition of α3β4 nAChR-mediated currents. a Typical traces of nicotine-induced whole-cell currents before (i, black) and after (ii, red) cocaine exposure. ai + ii shows a comparison of current rising and decay kinetics after superimposition of ai and aii with similar peak amplitudes. b Single exponential fitting of the whole-cell current rising time during nicotine exposure before (black) and after (red) cocaine exposure and showed no significant difference after cocaine exposure. c Cocaine significantly accelerated the whole-cell current decay constant. *P < 0.05 (baseline vs. cocaine exposure)