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Estimated mean reductions in ALT, AST, and IgM from OCA initiation. The black solid line represents fixed effects, gray solid lines are 95% CI, and dotted lines are individual values of patients with at least two measurements. ALT, AST, and IgM at 3, 6, 9, and 12 months are reduced compared to initiation (P < 0.01, P ≤ 0.05, P < 0.01, respectively, for all comparisons).
