Fig. 3.

TLR4 deficiency reversed the reduction in the TH protein level and number of TH-positive dopamine neurons induced by MPTP. a and c Immunohistochemical staining and quantitative analysis of TH in the SNpc (scale bar = 500 μm, 200 μm). b and d Immunohistochemical staining and quantitative analysis of TH in the striatum (scale bar = 1000 μm, 200 μm). e Western blotting results for TH protein levels in the striatum. The data are expressed as the mean ± SD (n = 3). **P < 0.01 vs. control group of WT mice; ^&P < 0.05, ^&&P < 0.01 vs. control group of TLR4-deficient mice; ^#P < 0.05, ^##P < 0.01 vs. MPTP-treated WT mice