Table 1.
Twenty-two identified plasma metabolites from GC/MS
| Primary ID | UUO vs Control | UUO + AA vs UUO | ||||||
|---|---|---|---|---|---|---|---|---|
| m/z | FCa | T-testb | FDRc | AUCd | FC | T-test | AUC | |
| Lactic acid | 147 | 1.53 | 2.78 × 10−2 | 5.10 × 10−2 | 1.00 | 0.42 | 5.96 × 10−3 | 0.89 |
| Urea | 147 | 1.92 | 2.96 × 10−4 | 6.52 × 10−3 | 1.00 | 0.55 | 1.25 × 10−3 | 1.00 |
| L-serine | 204 | 2.13 | 9.81 × 10−3 | 2.70 × 10−2 | 0.94 | 0.49 | 3.93 × 10−2 | 0.83 |
| L-threonine | 218 | 2.98 | 7.14 × 10−3 | 2.62 × 10−2 | 1.00 | 0.37 | 1.43 × 10−2 | 0.97 |
| D-galactose | 319 | 1.77 | 1.74 × 10−2 | 3.82 × 10−2 | 0.97 | 0.82 | 5.25 × 10−1 | 0.61 |
| Palmitic acid | 117 | 2.87 | 2.43 × 10−3 | 2.67 × 10−2 | 1.00 | 0.83 | 4.04 × 10−1 | 0.67 |
| Elaidic acid | 117 | 2.25 | 3.28 × 10−2 | 5.55 × 10−2 | 0.86 | 0.90 | 7.67 × 10−1 | 0.58 |
| Xanthotoxin | 341 | 2.50 | 2.20 × 10−2 | 4.41 × 10−2 | 1.00 | 1.10 | 7.65 × 10−1 | 0.56 |
| Pyruvic acid | 174 | 0.61 | 1.31 × 10−2 | 3.21 × 10−2 | 0.97 | 0.67 | 9.85 × 10−2 | 0.78 |
| Glycine | 102 | 2.06 | 6.05 × 10−3 | 2.66 × 10−2 | 0.94 | 0.48 | 4.94 × 10−2 | 0.86 |
| 3-Hydroxybutyric acid | 191 | 1.96 | 4.91 × 10−2 | 7.71 × 10−2 | 0.97 | 0.35 | 1.63 × 10−2 | 1.00 |
| L-valine | 144 | 0.51 | 2.90 × 10−3 | 2.12 × 10−2 | 0.97 | 1.78 | 1.51 × 10−1 | 0.78 |
| L-phenylalanine | 218 | 1.57 | 3.50 × 10−3 | 1.93 × 10−2 | 0.94 | 0.90 | 7.15 × 10−1 | 0.53 |
| Citric acid | 273 | 0.37 | 8.16 × 10−3 | 2.57 × 10−2 | 1.00 | 2.39 | 1.65 × 10−1 | 0.64 |
| Linoleic acid | 73 | 1.71 | 4.12 × 10−1 | 5.04 × 10−1 | 0.94 | 2.12 | 5.18 × 10−3 | 0.78 |
| 15d-PGJ2 | 258 | 1.04 | 8.73 × 10−1 | 8.73 × 10−1 | 0.56 | 3.43 | 5.31 × 10−3 | 0.86 |
| L-alanine | 116 | 0.87 | 7.50 × 10−1 | 8.25 × 10−1 | 0.61 | 0.94 | 9.01 × 10−1 | 0.53 |
| L-glutamic acid | 156 | 0.84 | 4.18 × 10−1 | 4.84 × 10−1 | 0.61 | 2.27 | 1.78 × 10−1 | 0.58 |
| D-allose | 319 | 1.77 | 3.19 × 10−1 | 4.39 × 10−1 | 0.67 | 0.61 | 4.02 × 10−1 | 0.58 |
| Cholesterol | 329 | 3.80 | 1.56 × 10−1 | 2.29 × 10−1 | 0.61 | 0.59 | 4.61 × 10−1 | 0.56 |
| L-isoleucine | 158 | 1.27 | 3.76 × 10−1 | 4.87 × 10−1 | 0.67 | 0.77 | 4.92 × 10−1 | 0.64 |
| Myo-inositol | 305 | 0.95 | 8.50 × 10−1 | 8.91 × 10−1 | 0.50 | 1.22 | 5.45 × 10−1 | 0.64 |
aFC: fold change value for each metabolite was calculated by comparing UUO group vs control group or UUO + AA group vs UUO group
bCritical P value of the Student’s t test
cFDR: adjusted P value of FDR correction by Benjamini–Hochberg method
dArea under the receiver operating characteristic (ROC) curve