Fig. 7. AMI and IMI relieved vascular dysfunction in HFD-fed rats.
Vascular responses to acetylcholine (ACh), leptin (Lep) and sodium nitroprusside (SNP) at a dose of 1 × 10−9–1 ×10−4 M were determined in the thoracic aorta (a–c). Summarized data showing the effect of AMI and IMI on the AUCs in response to ACh, Lep and SNP (d). Vascular concentration–response curves of the thoracic aorta to phenylephrine (Phe) in the absence (e) and presence of L-arginine (L-Arg, 1 × 10−4 M) (f) or L-NG-nitroarginine (L-NNA, 1 × 10−4 M) (g) were obtained. The ΔAUC of the contractile response to Phe represented the change in induced NO release and the basal NO level (h). The data are the means ± SEMs from six experiments. *P < 0.05 vs. control (Ctrl); #P < 0.05 vs. HFD-fed rats.