Skip to main content
. 2019 Dec 17;41(5):650–660. doi: 10.1038/s41401-019-0328-3

Fig. 8. Schematic diagram showing the effect of ASM downregulation on leptin resistance.

Fig. 8

ASM downregulation ameliorated endothelial leptin resistance and improved the Ob-Rb/STAT3/Akt/eNOS signaling pathway to increase NO production, consequently resulting in the relief of vasodilatation dysfunction.