Fig. 1.

Peripheral metabolic profiles. a, b Body weight of C56 BL/6 mice before Hup A delivery (LFD and HFD; n = 11 and 12, respectively). c, d Glucose tolerance test of 7-month-old mice (LFD and HFD; n = 5 and 4, respectively). e, g Body weight during Hup A delivery (LFD-Veh, n = 11; HFD-Veh, n = 7; HFD-0.1, n = 9; HFD-0.3, n = 7; ob/ob-Veh, n = 6; ob/ob-0.1, n = 7 and ob/ob-0.3, n = 7). f Glucose tolerance test of 9-month-old mice after two months of Hup A delivery. h Nonfasting blood glucose test during Hup A delivery (n = 4 in each group). Data are presented as the mean ± SEM. Data are compared using Student’s t test b, d and two-way ANOVA with Bonferroni post hoc test a, c, e–g. *P < 0.05; **P < 0.01; ***P < 0.001. There was no significant difference among the Hup A groups