Figure 5.

Unsupervised heatmap of muscle biopsies of defined histological severity clustered by mRNA expression levels of corresponding serum proteins from the TTSTAND (A) and 6MWT (B) models. mRNA levels were scaled, log-transformed data from a muscle biopsy data set on BMD, DMD and healthy control samples (2). The serum proteins selected by the TTSTAND and 6MWT models showed discriminatory power in differentiating muscle biopsies of variable histological severity, with distinct dendrogram branches for normal (left), mild (right) and severe (center) pathologies.