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. 2020 Jul 21;29(15):2611–2624. doi: 10.1093/hmg/ddaa158

Figure 1.

Figure 1

Epigenetic landscape of chromatin accessibility in the retina and RPE/choroid. Circos plots showing genome-wide chromatin accessibility as ATAC-Seq peaks in the retina and RPE/choroid (RPE/c) of (A) photosensitive Abca4−/−Rdh8−/− (dKO) mice reared under normal lighting conditions and 1 day after exposure to bright light stress (bleached), and (B) humans with and without AMD (generated from raw human sequencing data deposited in NCBI’s Gene Expression Omnibus (GEO) under accession number GSE99287). (C) Chromatin accessibility changes induced by photobleaching. Average ATAC-Seq signal in key genes for non-bleached (NB, n = 5) and bleached dKO retina 6 h (n = 3) and 1 day (n = 6) after bright light exposure. TSS, transcriptional start site; kb, kilobases.