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. 2020 Aug 21;8:771. doi: 10.3389/fcell.2020.00771

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Copyright © 2020 Verheijen, Suttorp, van Rheden, Regan, Helmich, Kuijpers-Jagtman and Wagener.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fetal body weight decreases by disruption of HO-2, but increases by HO-activity inhibition from E11. (A) Bar chart of the fetal body weight of the wt E15 fetuses (n = 15) and HO-2 KO E15 fetuses (n = 4), ^∗p < 0.05. Data are shown as mean ± SD. (B) Representative fetus per group was shown (centimeter ruler). (C) Box-and-whisker plot with 10–90 percentiles of quantitative assessment of the body weight of the wt CD1 E16 fetuses (n = 91) and wt CD1 SnMP E16 fetuses (n = 56), ^∗∗∗p < 0.001. (D) Representative fetus per group was shown (centimeter ruler).