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MES disintegration despite HO-2 abrogation and palatal fusion despite HO-activity inhibition from E11. In the HE-stained coronal palatal sections of the wt E15 and HO-2 KO E15 fetuses, the palatal shelves were attached and disintegration of the MES was found. In the HE-stained coronal palatal sections from wt CD1 E16 and wt CD1 SnMP E16 fetuses, the palatal shelves were fused. Representative palatal section per group was shown.
